ArticleReviews in cardiovascular medicine2026
Association of Triglyceride-Glucose Index With In-Hospital Malignant Arrhythmias in Older Patients With Diabetes Mellitus and Left Ventricular Aneurysm: A Retrospective Study.
Article in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Left ventricular aneurysm (LVA), a severe post-myocardial infarction (MI) complication, predisposes patients to malignant arrhythmias. The triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to adverse cardiac outcomes. Nevertheless, the association between the TyG index and in-hospital malignant arrhythmias in older, diabetic patients with LVA remains unclear. Methods: This retrospective study (the First Affiliated Hospital of Wenzhou Medical University, China) consecutively enrolled 655 patients with LVAs (aged ≥60 years with confirmed diabetes) from 2004 to 2024. The relationship between the TyG index quartiles and in-hospital malignant arrhythmias was evaluated using Kaplan-Meier (K-M) curves, Cox regression, and restricted cubic spline (RCS) analyses. Mediation analysis was employed to investigate underlying inflammatory pathways. Results: Participants had a median age of 75 years, and 57.56% were males. The RCS analysis indicated that elevated TyG index values were associated with a higher risk of in-hospital malignant arrhythmias; compared with the lowest quartile (Q1), the highest quartile (Q4) showed a nearly threefold higher risk (hazard ratio [HR] = 2.99; 95% confidence interval [CI]: 1.26-7.13). Exploratory pathway analyses indicated that neutrophils (NEs), white blood cells (WBCs), and the systemic inflammation response index (SIRI) partially accounted for this association. Subgroup analyses revealed no significant interactions. Conclusions: This study shows that the TyG index is independently associated with in-hospital malignant arrhythmias in older patients with LVA, serving as a simple, clinically relevant marker to identify high-risk individuals and guide targeted management.
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