Evidence map›Paper›PMID 42239081›Full record

ArticlebioRxiv : the preprint server for biology2026

Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes.

Ipsita G Kundu, Nicolas Toro, Aaron Y Mochizuki, Jaldeep Langhnoja, Rithvik V Ayyagari, James C Cronk, Sarah M Reel, Phonepasong Arounleut, Luis Tron Esqueda, Christine E Fuller and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ipsita G KunduDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH.
Nicolas ToroDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH.
Aaron Y MochizukiDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
Jaldeep LanghnojaDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH.
Rithvik V AyyagariDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH.
James C CronkDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
Sarah M ReelDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
Phonepasong ArounleutDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH.
Luis Tron EsquedaDepartment of Pharmacology, Physiology, and Neurobiology, College of Medicine, University of Cincinnati, Cincinnati, OH.
Christine E FullerDepartment of Pathology, SUNY Upstate Medical University, Syracuse, New York.
Pavithra ViswanathDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA.
Amy B HeimbergerMalnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA; Department of Neurological Surgery, Northwestern University, Chicago, IL.
Craig M HorbinskiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.
Timothy N PhoenixDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH.ORCID 0000-0003-4771-4003

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hui Zhang · 2018 to 2026
$21.4M
Modulation of Microglia and T Cell Interactions in Malignant GliomaR01CA120813 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, GANESH · 2007 to 2025
$4.7M
Stinging the Glioma Immune LandscapeR01NS120547 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, ARVIND · 2020 to 2023
$1.1M
NCI NIH HHS P50 CA221747NCI NIH HHS R01 CA120813NIDDK NIH HHS P30 DK078392NINDS NIH HHS R01 NS120547
6 · The paper itself

Abstract

Oligodendroglioma is a primary central nervous system tumor classified by the presence of isocitrate dehydrogenase (IDH) mutations and codeletion of 1p/19q. Here we describe the generation of an IDH-mutant 1p/19q-codeleted oligodendroglioma mouse model using in utero electroporation. We identified IDH1

Identifiers

PMID42239081
PMCPMC13228301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.