Evidence map›Paper›PMID 42239150›Full record

ArticlebioRxiv : the preprint server for biology2026

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation.

Santanu Ghosh, Andrew F Jarvis, Jordi C J Hintzen, Nate R McKnight, Pedro Costa-Pinheiro, Noelle H Noughton, Yumi Kim, Alison Jaccard, Scot C Leary, Paul A Cobine and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Santanu GhoshDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Andrew F JarvisDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jordi C J HintzenDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Nate R McKnightDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Pedro Costa-PinheiroDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Noelle H NoughtonDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yumi KimDepartment of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA.
Alison JaccardDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Scot C LearyDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada.
Paul A CobineDepartment of Biological Sciences, Auburn University, Auburn, AL, USA.
Caroline R BartmanDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gina M DeNicolaDepartment of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA.
Nathaniel W SnyderAging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0001-5643-8747
Kathryn E WellenDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
George M BurslemDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2812-983X
Donita C BradyDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2786-2802

Funding

Molecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and MetabolismR35GM124749 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Donita C Brady · 2017 to 2026
$4.6M
Editing Acetylation and Protein HomeostasisR35GM142505 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI George Burslem · 2021 to 2026
$2.7M
Unlocking the Chemical Space of Cancer-Associated PerturbationsR01CA280833 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BRADY, DONITA C, BURSLEM, GEORGE · 2022 to 2025
$2.2M
Measuring compartmentalized metabolism of cofactorsR35GM156596 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Nathaniel W. Snyder · 2025 to 2026
$555k
NCI NIH HHS R01 CA280833NIGMS NIH HHS R35 GM124749NIGMS NIH HHS R35 GM142505NIGMS NIH HHS R35 GM156596
6 · The paper itself

Abstract

Copper (Cu) is an essential cofactor for mitochondrial cytochrome

Identifiers

PMID42239150
PMCPMC13228588

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.