Evidence map›Paper›PMID 42239159›Full record

ArticlebioRxiv : the preprint server for biology2026

Adrenal Gland Macrophage-derived TGF-β Governs Vascular Permeability to Drive Monocyte Recruitment during Stress.

Yingzheng Xu, Michael T Patterson, Michael D Chang, Ian Ahlberg, Chi-Yun Liu, Charles Roll, Hannah Hillman, Ainsley Kennedy, Patricia R Schrank, Gage M Stuttgen and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yingzheng XuCenter for Immunology.
Michael T PattersonCenter for Immunology.
Michael D ChangCenter for Immunology.
Ian AhlbergCenter for Immunology.
Chi-Yun LiuDepartment of Integrative Biology & Physiology.
Charles RollCenter for Immunology.
Hannah HillmanCenter for Immunology.
Ainsley KennedyCenter for Immunology.
Patricia R SchrankCenter for Immunology.
Gage M StuttgenCenter for Immunology.
Yoshiaki KubotaKeio University School of Medicine, Tokyo, Japan.
Stoyan IvanovUniversité Côte d'Azur, CNRS, LP2M, Nice, France.
Bryce A BinstadtCenter for Immunology.
Jesse W WilliamsCenter for Immunology.ORCID 0000-0003-3815-0891

Funding

Sex and stress hormones control adrenal gland macrophage development and function"R01AI165553 · NIAID · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2022 to 2025
$2.2M
Regulation of Foamy Macrophage Differentiation and Survival in AtherosclerosisR01HL166843 · NHLBI · UNIVERSITY OF MINNESOTA · PI Jesse Warren Williams · 2024 to 2026
$1.6M
Inclusive Excellence Training Program in the Systems Biology of Cardiovascular InflammationT32HL166142 · NHLBI · UNIVERSITY OF MINNESOTA · PI JOSEPH Mark METZGER · 2023 to 2026
$817k
Targeting Trem2 in Atherosclerosis ProgressionF31HL182131 · NHLBI · UNIVERSITY OF MINNESOTA · PI Hannah Hillman · 2025 to 2026
$75k
NHLBI NIH HHS F31 HL182131NHLBI NIH HHS R01 HL166843NHLBI NIH HHS T32 HL166142NIAID NIH HHS R01 AI165553
6 · The paper itself

Abstract

The adrenal glands are central regulators of systemic stress responses through tightly controlled glucocorticoid production. Yet, the contribution of local immune-vascular interactions to adrenal stress adaptation remains poorly understood. Here, we investigated the role of adrenal gland macrophages in coordinating stress-induced immune remodeling and vascular function. By integrating single-cell RNA sequencing datasets across four distinct stress models, including acute cold exposure, chronic social defeat, chronic inflammation, and systemic

Identifiers

PMID42239159
PMCPMC13228538

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.