Evidence map›Paper›PMID 42239208›Full record

ArticlebioRxiv : the preprint server for biology2026

Artur S Gevorgyan, Lila M Gordon, Christian A Combs, Adrian Lita, Linda G Yang, Carla Cuní-López, Jessica T Root, Mioara Larion, Justin W Taraska, Priyanka S Narayan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Artur S GevorgyanGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD USA.
Lila M GordonBiochemistry and Biophysics Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Christian A CombsLight Microscopy Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4656-4840
Adrian LitaNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0115-6077
Linda G YangGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD USA.ORCID 0000-0002-1671-8792
Carla Cuní-LópezGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD USA.ORCID 0000-0001-8804-8970
Jessica T RootGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD USA.ORCID 0000-0002-9150-9579
Mioara LarionNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7016-9587
Justin W TaraskaBiochemistry and Biophysics Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5355-9535
Priyanka S NarayanGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD USA.ORCID 0000-0002-9328-4959

Funding

Investigating the molecular basis of risk and resilience to Alzheimer's diseaseZIADK075158 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NARAYAN, PRIYANKA · 2021 to 2025
$11.4M
Intramural NIH HHS ZIA DK075158
6 · The paper itself

Abstract

Disrupted endocytosis is an early feature of Alzheimer's disease (AD), but how genetic risk factors functionally impact this pathway remains unclear. Using isogenic human iPSC-derived astrocytes, we show that the AD risk variant,

Identifiers

PMID42239208
PMCPMC13228211

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.