Evidence map›Paper›PMID 42239299›Full record

ArticlebioRxiv : the preprint server for biology2026

Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA delivery.

Sarah S Nasr, Owen E Tabah, Sahana Kumar, Gregg A Duncan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah S NasrFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Owen E TabahFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Sahana KumarFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
Gregg A DuncanFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.

Funding

Understanding alterations to mucus composition and function in asthmaR01HL160540 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI Gregg Duncan · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL160540
6 · The paper itself

Abstract

Pulmonary delivery of lipid nanoparticles (LNPs) remains an area of significant interest, given the broad range of genetic disorders that could be addressed through localized administration of therapeutic nucleic acids to the lung. In this study, we investigated how incorporation of the clinically used lung surfactant cocktail Poractant alfa affects the

Indexed as

endosomal escapelipid nanoparticlesPoractant-alphapulmonary mRNA delivery

Identifiers

PMID42239299
PMCPMC13228340

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.