Evidence map›Paper›PMID 42239361›Full record

ArticlebioRxiv : the preprint server for biology2026

Abigail Fern, Jasmine Alexander-Floyd, Anhelina Volchok, Susan M Cahill, Srikar Donepudi, Jana Smuts, Tali Gidalevitz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Abigail FernBiology Department, Drexel University, Philadelphia, PA. USA.
Jasmine Alexander-FloydBiology Department, Drexel University, Philadelphia, PA. USA.ORCID 0000-0003-1894-0060
Anhelina VolchokBiology Department, Drexel University, Philadelphia, PA. USA.ORCID 0009-0009-2450-6763
Susan M CahillBiology Department, Drexel University, Philadelphia, PA. USA.
Srikar DonepudiBiology Department, Drexel University, Philadelphia, PA. USA.ORCID 0009-0002-3335-6161
Jana SmutsBiology Department, Drexel University, Philadelphia, PA. USA.
Tali GidalevitzBiology Department, Drexel University, Philadelphia, PA. USA.ORCID 0000-0002-9178-6648

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
The effect of juevnille protective programs on protein aggregation during agingR36AG045411 · NIA · DREXEL UNIVERSITY · PI ALEXANDER-FLOYD, JASMINE JANCOLA · 2013 to 2014
$129k
NIA NIH HHS R36 AG045411NIH HHS P40 OD010440
6 · The paper itself

Abstract

Small heat-shock proteins (sHSPs) are an ancient and diverse class of molecular chaperones, acting as a first line of defense against proteotoxic stresses. While the canonical sHSPs prevent uncontrollable aggregation of a broad range of non-native substrates, a subset of sHSPs do not exhibit this broad activity

Indexed as

chaperonesHSP-12.6muscle proteostasismyofilamentsprotein aggregationsmall heat shock proteins

Identifiers

PMID42239361
PMCPMC13228505

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.