Evidence map›Paper›PMID 42239416›Full record

ArticlebioRxiv : the preprint server for biology2026

A generalizable system for antigenic peptide targeting across HLA-I allotypes.

Wyatt Blackson, Ean L Small, Shirley M Sun, Omkar Shinde, Ram Pantula, Sean J Wang, Photis Rotsides, Haotian Du, Yi Sun, Daniel Hwang and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Wyatt BlacksonDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2452-5915
Ean L SmallCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Shirley M SunCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0007-6764-5750
Omkar ShindeCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ram PantulaCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sean J WangDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0379-4788
Photis RotsidesCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-2985-9954
Haotian DuDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Yi SunCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Daniel HwangCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-6071-8271
Chloe S WangCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tianyu LuDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3365-1542
Eli LaskawyCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Richa KapoorDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-4183-1332
Muzamil Y WantDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-9675-8910
Carl H JuneCenter for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0241-3557
Regina M YoungCenter for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0158-9449
John M MarisDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-8088-7929
Po-Ssu HuangDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7948-2895
Nikolaos G SgourakisCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3655-3902

Funding

Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomesR35CA220500 · CHILDREN'S HOSP OF PHILADELPHIA · 2025 to 2025
$1.1M
NCI NIH HHS R35 CA220500
6 · The paper itself

Abstract

T cell receptors (TCRs) and TCR-mimicking antibodies recognize peptide antigens in the context of specific Human Leucocyte Antigen (HLA-I) allotypes, and the extreme polymorphism of the HLA locus limits the breadth of immunotherapy development. Key barriers include divergent molecular surfaces on HLA proteins and differences in the peptide structure. As a result, existing modalities cannot confer therapeutic coverage across patients of divergent genetic backgrounds. Here, we develop an approach which combines a peptide conformational prediction tool, PepPred, with a cross-HLA binding protein engineering system, TRACeR-I

Identifiers

PMID42239416
PMCPMC13228281

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.