ArticlebioRxiv : the preprint server for biology2026
Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
20 authors.
Funding
Abstract
Background: Both rare and common variants in the SRY-Box Transcription Factor 17 ( Hypothesis: Impaired Methods and Results: We defined thousands of genes with direct SOX17 genomic binding sites and identified important potential binding partners, including ETS-transcription factors such as ERG by ChIP-seq in PAECs. Through the integration of three PAEC RNA-seq datasets involving overexpression and silencing of Conclusion: We have demonstrated the therapeutic potential of targeting SOX17 in PAH through correction of its gene targets, identifying BX-912 as a lead compound with
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Registered trials
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