Evidence map›Paper›PMID 42239466›Full record

ArticlebioRxiv : the preprint server for biology2026

Multi-site temporal control of optogenetic stimulation enhances firing frequencies in peripheral nerves.

Tarah A Welton, Tyler Currie, Arjun Fontaine, John Caldwell, Richard F Weir, Diego Restrepo, Emily A Gibson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tarah A WeltonDepartment of Biomedical Engineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0009-0007-8728-4745
Tyler CurrieDepartment of Biomedical Engineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0001-5762-324X
Arjun FontaineDepartment of Biomedical Engineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-1043-9538
John CaldwellDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-0503-6155
Richard F WeirDepartment of Biomedical Engineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-6597-1284
Diego RestrepoDepartment of Physiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-4972-446X
Emily A GibsonDepartment of Biomedical Engineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-3436-1483

Funding

Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out SpecificityR01NS118188 · NINDS · UNIVERSITY OF COLORADO DENVER · PI CALDWELL, JOHN H, GIBSON, EMILY · 2020 to 2024
$3.3M
NINDS NIH HHS R01 NS118188
6 · The paper itself

Abstract

We find that multi-site temporal control of optogenetic photostimulation in peripheral nerves can enhance firing rates by overcoming the intrinsic limitation of opsin photophysics. The benefits of multi-site optogenetic stimulation were demonstrated with three approaches: (1)

Indexed as

light shapingoptogeneticsperipheral nervevagus nerve stimulation

Identifiers

PMID42239466
PMCPMC13228354

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.