Evidence map›Paper›PMID 42239477›Full record

ArticlebioRxiv : the preprint server for biology2026

Splicing of ultraconserved poison exons controls mitotic fidelity and stem cell viability.

Nathan K Leclair, Mattia Brugiolo, Isha Walawalkar, Marina Yurieva, Hyeon Gu Kang, Ryan Englander, Mallory Ryan, Caleb Heffner, Justin A McDonough, William C Skarnes and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathan K LeclairThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0002-0401-2549
Mattia BrugioloThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Isha WalawalkarThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0002-9152-6651
Marina YurievaThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0002-5761-0382
Hyeon Gu KangThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Ryan EnglanderThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0003-3549-1455
Mallory RyanThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0001-5428-0018
Caleb HeffnerThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-2631-6201
Justin A McDonoughThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0003-1283-5972
William C SkarnesThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0002-8334-3329
Steve MurrayThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-0594-1702
Olga AnczukówThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0003-0516-2677

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Anna Karolina Palucka · 1985 to 2026
$61.9M
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving CancerR01CA248317 · NCI · JACKSON LABORATORY · PI ANCZUKOW-CAMARDA, OLGA · 2021 to 2025
$2.7M
Mechanisms of post-transcriptional regulation of splicing factorsR01GM138541 · NIGMS · JACKSON LABORATORY · PI ANCZUKOW-CAMARDA, OLGA · 2020 to 2024
$2.1M
Investigating how splicing factor homeostasis shapes transcriptomes in pluripotency and differentiationF30GM163345 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Isha Walawalkar · 2026 to 2026
$47k
NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA248317NIGMS NIH HHS F30 GM163345NIGMS NIH HHS R01 GM138541
6 · The paper itself

Abstract

SR proteins are essential splicing regulators whose expression is controlled in part through poison exons (PEs) - ultraconserved non-coding exons that trigger nonsense-mediated decay - yet the biological functions of these elements remain undefined. Here, we show that homozygous deletion of

Identifiers

PMID42239477
PMCPMC13228269

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.