Evidence map›Paper›PMID 42239697›Full record

ArticleJADA foundational science2024

Detection of human papillomavirus infection in oral mucosal diseases: A single-center study.

Paolo Junior Fantozzi, Umberto Romeo, Gianluca Tenore, Gaspare Palaia, Chiara Ciolfi, Alessandra Pierangeli, Cira Rosaria Tiziana Di Gioia, Alessandro Villa

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Article in JADA foundational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paolo Junior FantozziDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Umberto RomeoDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Gianluca TenoreDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Gaspare PalaiaDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Chiara CiolfiDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Alessandra PierangeliLaboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Cira Rosaria Tiziana Di GioiaDepartment of Radiological, Oncological, and Anatomic Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Alessandro VillaDepartment of Orofacial Sciences, University of California San Francisco, San Francisco, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers but only a small proportion of oral cavity cancers. This study aimed to investigate the presence of HPV DNA in oral diseases to understand better the possible correlation between oral lesions and HPV infections. Methods: This was a cross-sectional study of 99 adult patients seen for the evaluation of oral diseases. All patients received an oral biopsy and histopathologic examination and a brush biopsy for HPV-DNA detection and genotyping by real-time polymerase chain reaction. Immunohistochemistry was used to assess p16INK4a expression. Results: HPV was identified in 15 of 99 (15.2%) patients (males, 66.6%). Patients with oral leukoplakia (OL) (46.6%), followed by patients with oral lichen planus (OLP) (33.3%) had the highest rate of HPV infection, with a predilection for the buccal mucosa (17.5%). Most patients with high-risk HPV infections had OLP (4/10, 40.0%), whereas most of the patients with low-risk HPV infections had nonreactive epithelial hyperkeratosis (3/6, 50.0%). Among all benign lesions, 19.0% were positive for any HPV infection. One patient with OL showing mild epithelial dysplasia had a positive p16INK4a expression. Conclusions: The highest rate of HPV infection was in male patients, patients with OL and OLP, and conditions affecting the buccal mucosa. Larger studies are needed to elucidate the role of HPV in the development of these conditions.

Indexed as

Human papillomavirusoral canceroral HPVoral infectionsoral leukoplakiaOral medicine

Identifiers

PMID42239697
PMCPMC13229034

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.