ArticleFrontiers in nutrition2026
Screening and functional verification of potential metabolites for high fertility in sows.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nutritional metabolism greatly influences the embryonic development and pregnancy outcomes. Exploring the metabolic differences between high and low fertility individuals plays pivotal roles in improving reproduction in mammals. Objective: The objective of this study was to explore and confirm the important metabolites influencing the reproductive potential of multiparous sows. Methods: Forty serum samples were collected from Landrace × Large White crossbred sows (3-5 parity) with high litter size (HL) (total litter size ≥ 16) and low litter size (LL) (total litter size ≤ 12) to conduct metabolomics and lipidomics, and differential analysis was applied to screen the potential important metabolite candidates. In addition, porcine trophectoderm cells (PTC) and porcine endometrial stromal cells (PEEC) were used to evaluate the effects of potential metabolite candidates on Results: Through integrated untargeted metabolomics and lipidomics in the serum of sows with different fertility, we identified 37 upregulated metabolites including 3-methylglutaric acid, allantoin, uridine 5'-monophosphate (UMP), asparagine, oxypurinol, oleamide, phosphatidylcholine (PC), and cholesterol ester (ChE) and 77 downregulated metabolites including cholic acid, chenodeoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid 24-glucuronide (CDCA-24G), triglyceride (TG), phosphatidylethanolamine (PE), and (O-acyl)-ω-hydroxy fatty acid (OAHFA). The altered metabolites were involved in arginine and proline metabolism, purine metabolism, sphingolipid metabolism, ether lipid metabolism, and phenylalanine, tyrosine and tryptophan biosynthesis. In addition, Conclusion: Our results suggest that asparagine and PC (18:0_22:6) may serve as potential key functional metabolites to enhance reproductive capacity. These findings highlight metabolic targets and potential nutritional strategies for improving fertility in mammals.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.