Evidence map›Paper›PMID 42239723›Full record

ArticleiScience2026

Integrative omics identify NID2 as a therapeutic target linking depression and colorectal cancer in humans.

Li Huang, Ji Wang, Haodong Tian, Wen Wang, Zhaowen Nie, Xuehao Cui, Lilong Zhang, Yu Jin, Yang Ding, Zhongchun Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li HuangDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Ji WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Haodong TianMedical Research Council Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Wen WangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Zhaowen NieDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Xuehao CuiJohn Van Geest Centre for Brain Repair and MRC Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Lilong ZhangDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Yu JinLab for Interdisciplinary Spatial Analysis, University of Cambridge, Cambridge, UK.
Yang DingLab for Interdisciplinary Spatial Analysis, University of Cambridge, Cambridge, UK.
Zhongchun LiuDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.
Honggang YuDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Lianlian WuDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is frequently comorbid with gastrointestinal malignancies, yet the biological links governing this relationship require precise characterization. Analysis of a prospective colonoscopy cohort (

Indexed as

health sciencesmedicineoncology

Identifiers

PMID42239723
PMCPMC13226881

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.