ArticleResearch square2026
Integrative Mapping of Regulatory Variation in African American Hepatocytes Using Colocalization and MPRA: Toward Precision Drug Response.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Genomic datasets informing pharmacogenomic discovery often underrepresent individuals of African ancestry, limiting understanding of ancestry-specific regulatory variation and its implications for precision medicine. This gap hampers accurate gene regulatory modeling and equitable delivery of precision medicine. Results: We generated an expression quantitative trait loci (eQTL) dataset from 75 primary human hepatocytes derived from cadaveric livers of African American (AA) donors and integrated these data with public liver eQTL resources.Cis-eQTL mapping identified 31,606 eQTLs (SNP-gene pairs), including regulatory variation in pharmacogenomic-relevant genes such as Conclusions: By integrating ancestry-specific eQTL mapping, colocalization, and functional assays, this study improves the resolution of causal regulatory variants in hepatocytes. Expanding diverse population cohorts and incorporating functional assays in relevant tissue will be crucial to further disentangle the complex genetic architecture of hepatic gene regulation. Our findings expand the understanding of regulatory mechanisms underlying pharmacogenomic traits and advance precision medicine in admixed populations.
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