Evidence map›Paper›PMID 42240193›Full record

ArticleImmunity, inflammation and disease2026

Systemic Inflammation and Central Neuronal Damage: The Relationship Between Neutrophil-to-Lymphocyte Ratio and Neuron-Specific Enolase in Acute Ischemic Stroke.

Ning Rong, Hongyan Li, Siyu Qian, Yiting Ya, Hongfu Tian, Ningning Wang, Yuehua Yu, De-Sheng Zhu, Min-Yuan Liu

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In one paragraph

Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ning RongDepartment of Neurology, The Fourth People's Hospital Affiliated to Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-4002-6489
Hongyan LiDepartment of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Siyu QianDepartment of Neurology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Yiting YaDepartment of Neurology, 411 Hospital of Shanghai University, Shanghai, China.
Hongfu TianDepartment of Neurology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-2655-862X
Ningning WangDepartment of Neurology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Yuehua YuDepartment of Neurology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
De-Sheng ZhuDepartment of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-2454-2173
Min-Yuan LiuDepartment of Neurology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.

Funding

China Stroke Association Whole Course Management of Cerebrovascular Disease Sailing Fund 202001fifth-round key discipline construction project of Qingpu District Health System ZD2023-2fifth-round talent training project of Qingpu District Health System MY2023-11
6 · The paper itself

Abstract

background and purposeThe systemic inflammatory response, quantified by the neutrophil-to-lymphocyte ratio (NLR), and central neuronal injury, reflected by serum neuron-specific enolase (NSE), are implicated in the pathogenesis of acute ischemic stroke (AIS). However, the association between these two processes remains inadequately explored at the population level. This study aimed to investigate the relationship between NLR and neuronal injury via circulating biomarkers in AIS.

methodsIn this cross-sectional study, 4272 consecutively enrolled AIS patients from a single center in China were included. Serum NSE levels were measured, and NLR was calculated from peripheral blood counts and log₂-transformed for analysis. The association between log

resultsSerum NSE levels and the prevalence of high NSE both increased significantly across tertiles of log

conclusionElevated NLR is independently associated with higher levels of serum NSE in patients with AIS, supporting a link between systemic inflammation and the extent of central neuronal injury. These findings provide epidemiological evidence for an interaction between circulatory inflammatory responses and brain damage following ischemic stroke. However, due to the cross-sectional design, causality cannot be inferred, and the modest discriminatory ability of NLR limits its potential as a standalone clinical marker.

Indexed as

Brain IschemiaInflammationIschemic StrokeLymphocytesNeuronsNeutrophilsPhosphopyruvate HydrataseStrokeAgedBiomarkersChinaCross-Sectional StudiesFemaleHumansLymphocyte CountMaleBiomarkersPhosphopyruvate Hydrataseacute ischemic strokebiomarkerinflammationneuron‐specific enolaseneutrophil‐to‐lymphocyte ratio

Identifiers

PMID42240193
PMCPMC13581072

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.