Evidence map›Paper›PMID 42240334›Full record

ArticleAntimicrobial agents and chemotherapy2026

Efficacy and safety of doravirine/lamivudine/tenofovir as initial treatment for people living with HIV in China.

Qianhui Chen, Yanhe Luo, Qi Zheng, Miao Tan, Songjie Wu, Shi Zou, Yuting Tan, Jie Liu, Shihui Song, Qian Du and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qianhui Chen *Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0009-0002-6651-9684
Yanhe Luo *Department of Infectious Diseases, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Qi Zheng *Department of Infectious Diseases, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Miao Tan *Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Songjie WuDepartment of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China.
Shi ZouDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0000-0003-0681-5123
Yuting TanDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jie LiuDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Shihui SongDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Qian DuDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ke HongDepartment of Infectious Diseases, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0008-6876-5102
Ke LiangDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0000-0003-0490-5328

Funding

National Natural Science Foundation of China 82500715Wuhan Medical Research Project of Wuhan Municipal Health Commission WG21B01
6 · The paper itself

Abstract

The newly approved oral anti-HIV doravirine (DOR)-based regimen in China in treatment-naïve people living with HIV (PLWH) remains inadequately characterized in China, particularly regarding antiviral efficacy and lipid profile changes. This study aimed to assess 48-week antiviral effectiveness and lipid changes associated with a DOR-based regimen in treatment-naïve PLWH compared with other regimens. A real-world retrospective study was conducted involving treatment-naïve PLWH who initiated DOR/TDF/3TC, EFV/TDF/3TC, DTG/TDF/3TC, or BIC/TAF/FTC. At week 48, 96.22% of participants receiving DOR/TDF/3TC achieved viral suppression, accompanied by significant increases in CD4

Indexed as

Anti-HIV AgentsHIV InfectionsLamivudinePyridonesTenofovirTriazolesAdultCD4 Lymphocyte CountChinaFemaleHumansMaleMiddle AgedRetrospective StudiesTriglyceridesViral LoadAnti-HIV AgentsdoravirineLamivudinePyridonesTenofovirTriazolesTriglyceridesantiviral efficacydoravirine/lamivudine/tenofovirHIVinitial treatmentlipid profiles

Identifiers

PMID42240334
PMCPMC13321822

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.