ArticleJournal of enzyme inhibition and medicinal chemistry2026
Design, synthesis, and anti-inflammatory evaluation of novel analogues derived from the natural product reticuline.
Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
The natural alkaloid reticuline exhibits promising anti-inflammatory activity in preclinical models; however, its development is hindered by moderate potency and limited accessibility. To overcome these hurdles, we developed an efficient synthetic route to reticuline, enabling the design and synthesis of 21 structural analogues. Through systematic structure-activity relationship (SAR) exploration, compound
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