ArticleJournal of endocrinological investigation2026
Diagnostic classification and medical decision of idiopathic asthenozoospermia based on metabolomics analysis of seminal plasma.
Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic asthenozoospermia(IA) is diagnosed when decreased or absent sperm motility is observed without an identifiable cause through standard clinical evaluations. So far, there have been no reports on the metabolomic classification of IA.
methodsSeminal plasma metabolites were profiled using gas chromatography-mass spectrometry (GC-MS) in 52 healthy controls and 50 patients with IA. Non-negative matrix factorization (NMF) was applied to 62 identified metabolites to classify IA cases into metabolic subtypes, followed by multivariate analyses to characterize the metabolic dysregulation patterns across clusters.
resultsNMF identified three distinct IA subtypes with progressively dysregulated metabolic profiles. Eight core metabolites, including citric acid and cholesterol, were consistently altered across all clusters, suggesting shared pathophysiological mechanisms. Cluster 1 showed 10 unique differential metabolites, particularly reduced inositol levels. Cluster 2 was characterized by significantly higher glucose levels compared with other asthenozoospermia cases. Cluster 3 displayed markedly elevated pyruvate levels as a key metabolic feature.
conclusionThis study provides the first NMF-based metabolomic classification of IA, revealing heterogeneous metabolic signatures among patients. These findings may support refined diagnostic classification and more rational clinical drug use for IA.
Indexed as
Identifiers
42240752What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.