Evidence map›Paper›PMID 42241704›Full record

ReviewBlood advances2026

Novel therapies for von Willebrand disease.

Cécile V Denis, Hachem Dich, Caterina Casari

Abstract readReview
In one paragraph

Review in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cécile V DenisLaboratory for Hemostasis, Inflammation & Thrombosis, INSERM UMR-S1176, University Paris-Saclay, Le Kremlin-Bicêtre, France.ORCID 0000-0001-5152-9156
Hachem DichLaboratory for Hemostasis, Inflammation & Thrombosis, INSERM UMR-S1176, University Paris-Saclay, Le Kremlin-Bicêtre, France.
Caterina CasariLaboratory for Hemostasis, Inflammation & Thrombosis, INSERM UMR-S1176, University Paris-Saclay, Le Kremlin-Bicêtre, France.ORCID 0000-0002-8271-6795

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractFor the past decades, treatment for von Willebrand disease has essentially consisted of classic approaches, and only in the past few years has the need for more innovative strategies been recognized. To address the needs of groups of patients with similar phenotypes and bleeding, personalized therapeutic strategies are being developed, molecules designed for other bleeding disorders are being repositioned, and new hemostatic agents are being tested in patients with von Willebrand disease. New therapeutics include a variety of molecules, including antibodies, engineered factors, synthetic nanoparticles, small interfering RNAs, and genome editing tools. Some promising molecules are still undergoing preclinical testing, whereas others have already entered clinical evaluation and may soon be available for at least some patients with von Willebrand disease. We believe that new approaches will improve the clinical management and the quality of life for patients with von Willebrand Disease.

Indexed as

von Willebrand DiseasesAnimalsGene EditingGenetic TherapyHumansRNA, Small Interferingvon Willebrand FactorRNA, Small Interferingvon Willebrand Factor

Identifiers

PMID42241704
PMCPMC13449370

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.