Evidence map›Paper›PMID 42242213›Full record

ArticleStem cell reports2026

Functional maturation of enteric neurons derived from human induced pluripotent stem cells.

Eve S Rowland, Maciej Daniszewski, Caio Seguin, Maria A Di Biase, Gunes S Yildiz, Atefeh Namipashaki, Alice Pébay, Faranak Fattahi, Lincon A Stamp, Marlene M Hao

Abstract read
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In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eve S RowlandDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia.
Maciej DaniszewskiDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia.
Caio SeguinDepartment of Psychiatry, the University of Melbourne, Melbourne, VIC, Australia.
Maria A Di BiaseDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia; Department of Psychiatry, the University of Melbourne, Melbourne, VIC, Australia; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gunes S YildizDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia.
Atefeh NamipashakiDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia.
Alice PébayDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia; Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia.
Faranak FattahiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Lincon A StampDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia. Electronic address: lstamp@unimelb.edu.au.
Marlene M HaoDepartment of Anatomy and Physiology, the University of Melbourne, Melbourne, VIC, Australia. Electronic address: hao.m@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enteric nervous system (ENS) plays a crucial role in regulating gastrointestinal function, including motility, secretion, and absorption. Enteric neurons and glia derived from human induced pluripotent stem cells (iPSCs) have vast applications in disease modeling, drug screening, and cell replacement therapy, yet our understanding of their functional maturation remains limited. Using a defined protocol for the generation of iPSC-derived enteric neurons, we examined neuronal differentiation with immunohistochemistry, gene expression analysis, and cellular-resolution calcium (Ca

Indexed as

Cell DifferentiationEnteric Nervous SystemInduced Pluripotent Stem CellsNeuronsCalciumCells, CulturedHumansNeurogliaCalciumcalcium imagingenteric gliaenteric nervous systementeric neuroninduced pluripotent stem cellneuronal differentiation

Identifiers

PMID42242213
PMCPMC13385724

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.