Evidence map›Paper›PMID 42242519›Full record

ArticleMucosal immunology2026

Tuft cells protect against intestinal inflammation through histone deacetylase 3.

Emily M Eshleman, Taylor Rice, Amanda Waddell, Samarth Kumar, Bailey J Didriksen, Laura Engleman, Sybele Vidyant, Mohammed Sayed, Rebekah Karns, Hee-Woong Lim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emily M EshlemanDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: emily.eshleman@cchmc.org.
Taylor RiceDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Amanda WaddellDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Samarth KumarDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Bailey J DidriksenDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Laura EnglemanDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Sybele VidyantDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Mohammed SayedDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Rebekah KarnsDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Hee-Woong LimDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Lee A DensonDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Theresa AlenghatDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: theresa.alenghat@cchmc.org.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Xenotransplant and Genome Editing CoreU54DK126108 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Starczynowski, YI ZHENG · 2021 to 2026
$5.0M
Host integration of commensal and pathogenic bacterial-derived signalsR01DK116868 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2018 to 2026
$4.1M
Epigenetic regulation of intestinal tuft cellsR01DK137771 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2024 to 2026
$2.5M
Microbial regulation of intestinal tuft cell homeostasisK01DK135647 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Emily M. Eshleman · 2023 to 2026
$563k
NIDDK NIH HHS K01 DK135647NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK116868NIDDK NIH HHS R01 DK137771NIDDK NIH HHS U54 DK126108
6 · The paper itself

Abstract

While intestinal tuft cells are well known to promote type 2 immunity, their role in inflammatory bowel disease (IBD) remains unclear. Here, we show that tuft cells are reduced in the distal intestine of pediatric IBD patients and that tuft cell-deficient mice exhibited increased susceptibility to intestinal inflammation. Histone deacetylase 3 (HDAC3) expression in intestinal stem cells is essential for tuft cell differentiation. Interestingly, single-cell analyses revealed that HDAC3 was also enriched in mature tuft cells compared to other differentiated epithelial populations. Generation of tuft cell-specific HDAC3 knockout mice (HDAC3

Indexed as

ColitisHistone DeacetylasesInflammatory Bowel DiseasesIntestinal MucosaTuft CellsAnimalsCell DifferentiationChildDisease Models, AnimalHistone Deacetylase 3HumansInflammationMiceMice, KnockoutHistone Deacetylase 3Histone Deacetylases

Identifiers

PMID42242519
PMCPMC13485144

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.