Evidence map›Paper›PMID 42243263›Full record

ArticleScientific reports2026

Validation of the modified transplant symptom occurrence and symptom distress scale and exploring symptom burden in Brazilian kidney transplant recipients.

Niels L Riemersma, Tim J Knobbe, Renata M C Guedes, Juliana G Ferreira, Luciana A Cabanelas, Kris Denhaerynck, Sabina de Geest, Helady Sanders-Pinheiro, José M Pestana, Renato D Foresto and 2 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Niels L RiemersmaDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. N.L.Riemersma@umcg.nl.
Tim J KnobbeDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Renata M C GuedesDepartment of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, SP, Brazil.
Juliana G FerreiraDepartment of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, SP, Brazil.
Luciana A CabanelasHospital Do Rim, Fundação Oswaldo Ramos, São Paulo, SP, Brazil.
Kris DenhaerynckInstitute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
Sabina de GeestInstitute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
Helady Sanders-PinheiroRenal Transplantation Unit, Division of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.
José M PestanaHospital Do Rim, Fundação Oswaldo Ramos, São Paulo, SP, Brazil.
Renato D ForestoHospital Do Rim, Fundação Oswaldo Ramos, São Paulo, SP, Brazil.
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lúcio R Requião-MouraDepartment of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, SP, Brazil.

Funding

Groninger Universiteitsfonds 2024JN141Stichting De Cock-Hadders 2024-90
6 · The paper itself

Abstract

Kidney transplant recipients (KTR) may experience burdensome symptoms, including tremor, nausea, and bruises, sometimes caused by immunosuppressive medication, which can negatively influence health-related quality of life. The 59-item Revised Modified Transplant Symptom Occurrence and Symptom Distress scale (MTSOSD-59R) captures patients' symptom experience but has not been validated in Brazil. We evaluated the Brazilian Portuguese MTSOSD-59R regarding content validity (expert panel), internal structure (factor analysis), and associations with other variables (known-groups approach). Symptom occurrence and distress by sex and age were assessed using ridit analyses. 485 KTR (42.2% women; 50.2 ± 12.8 years) were included at median 7.4 [3.2-13.0] years post-transplantation. The expert-rated scale-content validity index was 0.49. Construct validity and known-group associations were confirmed. The most occurring symptoms were anxiety [ridit score: 0.697], tiredness [0.653], and difficulty seeing well [0.652]. The most distressing symptoms were menstrual problems [0.635], difficulty seeing well [0.606], and genital warts [0.595]. Female/younger KTR tended to report more (distress from) psychological/aesthetic symptoms; male/older KTR tended to report more (distress from) physical symptoms. The MTSOSD-59R showed validity for internal structure and relationships to other variables, but insufficient expert-rated content validity for immunosuppression-specific side effects, suggesting it may better reflect general symptom burden in this population.

Indexed as

Kidney TransplantationTransplant RecipientsAdultBrazilFemaleHumansMaleMiddle AgedQuality of LifeSurveys and QuestionnairesSymptom BurdenHealth-related quality of lifeKidney transplant recipientsMTSOSD-59RSymptom experienceValidation

Identifiers

PMID42243263
PMCPMC13478588

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.