ArticleChinese journal of integrative medicine2026
Efficacy and Mechanism of Silymarin Extract for Deep Second-Degree Burns in Rats.
Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectiveTo investigate the therapeutic efficacy of silymarin extract on deep second-degree burns in vivo and in vitro and elucidate the underlying molecular mechanisms.
methodsA total of 126 Sprague-Dawley rats were randomized into 7 groups using a random number table method (n=18), including normal control (NC), model, vehicle control (Veh), positive control (Mepore Moist Burn Gream, 25 mg/cm
resultsSilymarin extract treatment significantly accelerated wound closure and attenuated tissue edema in the scalded areas (P<0.05 or P<0.01). Histopathological assessment revealed that silymarin extract augmented collagen deposition and remodeling, promoted reepithelialization and regeneration of skin appendages, mitigated inflammatory cell infiltration, and facilitated necrotic tissue resolution (P<0.01). Mechanistically, silymarin extract upregulated the Nrf2 signaling pathway by promoting Nrf2 dissociation from Keap1. This activation potentiated antioxidant defenses (HO-1, NQO1, SOD, and GSH) and suppressed MDA (P<0.05 or P<0.01). Concurrently, silymarin extract significantly downregulated pro-inflammatory cytokines IL-1 and TNF-α (P<0.05 or P<0.01). These protective effects were abrogated in vitro by the specific Nrf2 inhibitor ML385.
conclusionSilymarin extract accelerates the healing of deep second-degree burns and mitigates oxidative stress-induced tissue injury by activating Nrf2 signaling axis, suggesting its potential as an effective therapeutic agent.
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