Trial reportBMC psychiatry2026
Insular spontaneous activity changes after dialectical behavior therapy skills training for depressed patients with non-suicidal self-injury: a randomized controlled trial.
Trial report in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04094623 (The Muti-centered Investigation，Pathogenesis and Intervention Study of Non-suicidal Self-injury Behavior in China), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Muti-centered Investigation，Pathogenesis and Intervention Study of Non-suicidal Self-injury Behavior in China
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-suicidal self-injury (NSSI) frequently co-occurs with major depressive disorder (MDD). This study aims to investigate the efficacy of dialectical behavior therapy skills training (DBT-ST) in treating major depressive disorder with non-suicidal self-injury (nsMDDs) under routine medication, as well as its modulatory effects on neural mechanisms.
methodsThis assessor-masked, multicenter, randomized controlled trial enrolled 80 patients with nsMDDs from outpatient or inpatient departments of four hospitals. Participants were randomly assigned to receive either DBT-ST or social support group therapy (SSGT) once weekly for 13 weeks. NSSI severity, depressive severity, and spontaneous brain activity were assessed in both training groups before and after the intervention. The data analysis was conducted using SPSS 23 and MATLAB 2013a.
resultsFindings demonstrated that both intervention groups were effective in alleviating clinical symptoms. Subgroup analyses by age revealed that DBT-ST demonstrated more significant improvements in NSSI behavior (B = 1.15, p < 0.001, d = -1.24) and depressive symptoms (B = 22.22, p < 0.001, d = -1.61) among adolescents (13 ~ 17 years old). Resting-state data revealed that following intervention, the DBT-ST group exhibited significantly reduced amplitude of low-frequency fluctuations (ALFF) in the right insula (F = 11.85, p = 0.003, d = 0.93) and regional homogeneity (ReHo) in the left insula (F = 18.48, p < 0.001, d = 1.24). Furthermore, following intervention, improvement in depressive symptoms within the DBT-ST group showed a significantly correlated with the reduction in ALFF in the right insula (r = 0.694, p = 0.038).
conclusionsDBT-ST may demonstrate superior applicability for improving clinical symptoms in adolescents with nsMDDs. Concurrently, DBT-ST may modulate abnormal spontaneous brain activity within neural circuits associated with nsMDDs. However, as this study did not track medication changes during the intervention period, the confounding effect of medication on neural alterations cannot be ruled out.
trial registrationClinicalTrials No.: NCT04094623, retrospectively registered 13 September 2019.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.