Evidence map›Paper›PMID 42244995›Full record

ArticleTheranostics2026

Primary Cilium Forces Neuroendocrine Shift in Prostate Cancer through YAP1 Repression and Reduced Mitochondrial Activity.

Yingbo Guo, Siyong Peng, Thibaud Jamet, Virginie Firlej, Marie Irondelle, Constance Nau, Christophe A Girard, Kaushal Asrani, Tamara L Lotan, Romain Huc and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yingbo GuoUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Siyong PengUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Thibaud JametUniv Paris Est Creteil, TRePCa, F-94010 Creteil, France.
Virginie FirlejUniv Paris Est Creteil, TRePCa, F-94010 Creteil, France.
Marie IrondelleUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Constance NauUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Christophe A GirardUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 11.
Kaushal AsraniDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tamara L LotanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Romain HucUniv Paris Est Creteil, TRePCa, F-94010 Creteil, France.
Pascale SoyeuxUniv Paris Est Creteil, TRePCa, F-94010 Creteil, France.
Matthieu RouleauUniversité Côte d'Azur, CNRS, LP2M, Nice, France.
Sandra Lacas-GervaisUniversité Côte d'Azur, Centre Commun de Microscopie Appliquée, CCMA, Nice, France.
Amandine RoviniUniversité de Limoges, INSERM UMR 1308, CAPTuR, Limoges, France.
Samantha LucianoCentre Antoine Lacassagne, Biological Resource Center, 33 Av. de Valombrose, 06100 Nice, France.
Olivier HumbertCentre Antoine Lacassagne, Department of Nuclear Medicine, 33 Av. de Valombrose, 06100 Nice, France.
Renaud SchiappaCentre Antoine Lacassagne, Department of Epidemiology, Biostatistics and Health Data, 33 Av. de Valombrose, 06100 Nice, France.France.
Marc Pujalte-MartinUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Mathieu VigneauUniversity of Toulouse, CNRS UMR 5070, INSERM U1301, EFS, ENVT, Institut RESTORE,Toulouse, France.
Pascal PeraldiUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Frédéric BostUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.
Gwendal LazennecUniversity of Toulouse, CNRS UMR 5070, INSERM U1301, EFS, ENVT, Institut RESTORE,Toulouse, France.
Francis VacherotUniv Paris Est Creteil, TRePCa, F-94010 Creteil, France.
Nathalie M MazureUniversité Côte d'Azur, INSERM U1065, C3M, 151 Route de St Antoine de Ginestière, BP2 3194, CEDEX 03, 06204 Nice, France - Equipe 5.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary cilia are increasingly recognized as regulators of cellular signaling and plasticity. Here, we examined their distribution and potential relevance in neuroendocrine (NE) prostate cancer. While typically absent in localized hormone-sensitive prostate tumor cells, we detected primary cilia in neuroendocrine-like cells both

Indexed as

Adaptor Proteins, Signal TransducingCiliaMitochondriaNeuroendocrine CellsProstatic NeoplasmsAnimalsCell Line, TumorHumansMaleMetabolic ReprogrammingTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsglycolysishypoxiamitochondrianeuroendocrine transdifferentiationprimary ciliumprostate cancerYAP1

Identifiers

PMID42244995
PMCPMC13232477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.