Evidence map›Paper›PMID 42245039›Full record

ArticlemedRxiv : the preprint server for health sciences2026

MethylCog predicts six-year cognitive ability beyond blood-based ADRD biomarkers.

Deirdre M O'Shea, Lily Wang, David Lukacsovich, Wei Zhang, James E Galvin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deirdre M O'SheaComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL.ORCID 0000-0003-3313-7655
Lily WangDivision of Biostatistics, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL.
David LukacsovichDivision of Biostatistics, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL.
Wei ZhangDivision of Biostatistics, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL.
James E GalvinComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca Raton, FL.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Health and Retirement Study: Harmonized Cognitive Assessment Protocol (HCAP)U01AG058499 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGA, KENNETH M · 2018 to 2023
$8.3M
Creating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
Miami Clinical and Translational Science Institute K12 ProgramK12TR004555 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALESSIA FORNONI, Tatjana Rundek · 2023 to 2026
$3.0M
New DNA methylation biomarkers for predicting AD and cognitive declineR61NS135587 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WANG, LILY · 2024 to 2025
$1.5M
NCATS NIH HHS K12 TR004555NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG058499NINDS NIH HHS R61 NS135587
6 · The paper itself

Abstract

introductionMethylCog is a 29-CpG blood DNA methylation (DNAm) proxy for general cognitive ability (g). Its incremental association with blood biomarkers of Alzheimer's disease and related dementias (ADRD) and prospective cognitive ability remains unclear.

methodsIn the held-out test set from the original MethylCog study, we tested whether MethylCog explained baseline

resultsMethylCog showed a stronger age-adjusted association with baseline DISCUSSION: MethylCog may provide cognition-related DNAm information complementary to blood-based ADRD biomarkers.

Indexed as

ADRDAlzheimer’s diseaseAβ42/40blood biomarkerscognitioncognitive agingDNA methylationepigeneticsGFAPHRS-HCAPneurofilament light chainpTau181

Identifiers

PMID42245039
PMCPMC13232370

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.