Evidence map›Paper›PMID 42245063›Full record

ArticlemedRxiv : the preprint server for health sciences2026

A Common

Saketh Challa, Kiran Biddinger, Sarah Abramowitz, Alice Zheng, Jonathan O Mead, Renae L Judy, Sean Jurgens, Liam Gaziano, Xin Wang, Seung Hoan Choi and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Saketh ChallaCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Kiran BiddingerCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Sarah AbramowitzDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Alice ZhengCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Jonathan O MeadDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Renae L JudyDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sean JurgensCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Liam GazianoCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Xin WangCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Seung Hoan ChoiCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Jennifer HalfordCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Elizabeth JordanDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Joseph LiuHeart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
VA Million Veteran Program
Penn Medicine Biobank
Kyong-Mi ChangCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Amanda VestHeart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
W H Wilson TangHeart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Philip TsaoPalo Alto Epidemiology Research and Information Center (ERIC) for Genomics, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Daniel D KinnamonDivision of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Scott M DamrauerDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Patrick T EllinorCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Michael LevinCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Ray E HershbergerThe Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.
Jennifer E HuffmanCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.
Krishna G AragamCardiovascular Disease Initiative, The Broad Institute of MIT & Harvard, Cambridge, MA, USA.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Population genomics in peripartum cardiomyopathyR01HL174912 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Krishna G Aragam · 2025 to 2026
$1.5M
Population Assessments of Aggregate Genetic Risk for DilatedýCardiomyopathyK08HL153937 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ARAGAM, KRISHNA G · 2021 to 2025
$846k
BLRD VA I01 BX003362BLRD VA IK2 BX006551NCATS NIH HHS UL1 TR001878NHLBI NIH HHS K08 HL153937NHLBI NIH HHS R01 HL174912
6 · The paper itself

Abstract

Importance: Dilated cardiomyopathy (DCM) is a major cause of heart failure that disproportionately affects individuals of African genetic ancestry (AFR), among whom familial clustering of disease is also more pronounced relative to those of European ancestry (EUR). However, established monogenic DCM genes, identified primarily in EUR populations, explain a smaller proportion of DCM cases in AFR populations. A recent study identified a common AFR-specific nonsense variant in Objective: To compare the contribution of a Design Setting and Participants: Multicohort genetic association study including AFR and EUR participants with exome or genome sequence and DCM case status from four datasets: All of Us, Million Veteran Program, Penn Medicine Biobank, and the DCM Precision Medicine Study. Exposure: Carrier status for Main Outcomes and Measures: Odds of DCM; prevalence of risk-variant carriers among DCM cases; and population attributable fraction (PAF) for DCM. Results: Among 82,623 AFR individuals across four studies, the mean age was 53.4 years and 1,625 had DCM. Conclusions and Relevance: An ancestry-specific

Identifiers

PMID42245063
PMCPMC13232372

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.