Evidence map›Paper›PMID 42245280›Full record

ArticleChina CDC weekly2026

Molecular Evolution in the Second Hypervariable Region of the G Gene for Human Respiratory Syncytial Virus Lineage A.D - Worldwide, 2010-2024.

Yuqing Shi, Zhen Zhu, Jinhua Song, Naiying Mao, Jie Jiang, Ke Lu, Na Wang, Liwei Sun, Linqing Zhao, Yonghao Guo and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in China CDC weekly, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuqing ShiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Zhen ZhuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Jinhua SongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Naiying MaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Jie JiangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Ke LuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Na WangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Liwei SunChildren's Hospital of Changchun, Changchun City, Jilin Province, China.
Linqing ZhaoLaboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing, China.
Yonghao GuoHenan Provincial Center for Disease Control and Prevention, Zhengzhou City, Henan Province, China.
Ruiqiu ZhaoDepartment of Infectious Diseases, Children's Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Jiahui XieMaster's Degree Virus Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, Guangdong Province, China.
Chao LiuShenyang Center for Disease Control and Prevention (Shenyang Health Inspection Institute), Shenyang City, Liaoning Province, China.
Ying ChenInner Mongolia Autonomous Region Academy of Preventive Medicine, Inner Mongolia Autonomous Region Center for Disease Control and Prevention, Hohhot City, Inner Mongolia Autonomous Region, China.
Feng ZhangLaboratory of Viral Diseases, Qingdao Municipal Centre for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao City, Shandong Province, China.
Junrui ChenJining Medical University, Jining City, Shandong Province, China.
Lei CaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Hongqiao HuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Baicheng XiaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.
Yan ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Disease, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Human respiratory syncytial virus subgroup A (HRSV-A) lineage A.D is characterized by a unique 72-nucleotide duplication in the second hypervariable region of the G-gene (G-HVR2) and has become the predominant global circulating strain since 2010. Molecular evolutionary features of this region should be monitored. Methods: A global HRSV-A G-HVR2 sequence dataset (2010-2024) was assembled that included 144 Chinese sequences and the molecular characteristics and evolutionary patterns in lineage A.D were analyzed. Results: Molecular clock analysis based on G-HVR2 estimated that HRSV-A lineage A.D originated in 2006, with subsequent diversification into four distinct lineages. A.D.4 and A.D.5 were grouped as A.D.4/A.D.5. Lineages circulate globally with temporal fluctuations and sequential dominance shifts. The evolutionary rate of A.D was high, with the highest rate observed in A.D.4/A.D.5. Amino acid analysis indicated five shared, lineage-specific mutations in A.D.1 and A.D.4/A.D.5 that coincided with high-frequency mutation sites. Nine positively-selected sites were predicted across all lineages, three of which resided within the 72-nucleotide duplication. A.D.1 and A.D.4/A.D.5 lost conserved N- and O-glycosylation sites. A 72-nucleotide duplication in lineage A.D introduced two extra β-strands and two unique α-helical motifs relative to the prototype strain. Conclusion: Adaptive evolution in the G-HVR2 region of HRSV-A lineage A.D was evident, likely facilitating the rapid transmission of this lineage. Sustained monitoring of lineage-specific evolution in this region is critical for targeted prevention and control of HRSV infections.

Indexed as

G-HVR2Human respiratory syncytial virus ALineage A.Dmolecular evolution

Identifiers

PMID42245280
PMCPMC13231391

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.