SynthesisFrontiers in microbiology2026
Effects of probiotic supplementation on diabetic kidney disease: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic kidney disease (DKD) is one of the leading causes of end-stage kidney disease worldwide, and microbiota-based interventions are considered potential preventive and therapeutic strategies to slow its progression. This study evaluated the efficacy of probiotic supplementation in patients with DKD through a systematic review and meta-analysis. Methods: We searched seven databases, including PubMed, Embase, the Cochrane Library (CENTRAL), CNKI, Wanfang, VIP and SinoMed, to identify all relevant studies published from database inception to July 2025. Eligible studies were randomized controlled trials assessing probiotic interventions in DKD patients. Study quality was evaluated using the Cochrane Risk of Bias tool, and meta-analyses were performed using R. Results: A total of 11 studies involving 726 participants were included. Probiotic supplementation significantly improved serum creatinine (MD - 0.17, -0.22 to -0.12, Conclusion: Probiotic supplementation may improve metabolic disturbances, renal function, and systemic inflammation/oxidative stress in DKD patients. However, its clinical efficacy and long-term effects require further validation in large-scale studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.