ArticleFrontiers in microbiology2026
Calcium controls type III secretion switch through an SctV-SctW interplay.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Type III secretion (T3S) is employed by many Gram-negative pathogens to inject toxins into eukaryotic cells via a syringe-like nanomachine, the injectisome. Secretion of T3 substrates follows a hierarchical order: early substrates and translocators are secreted first to assemble the injectisome, followed by effectors that initiate infection. Gatekeeper proteins and environmental signals, such as calcium, are known to regulate the secretion switch from translocators to effectors; however, the underlying molecular mechanism remains elusive. In this study, we demonstrate that the gatekeeper SctW and the export apparatus component SctV bind Ca
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