ArticleFrontiers in behavioral neuroscience2026
Associations of metabolic syndrome with minimal hepatic encephalopathy in patients with cirrhosis and portal hypertension: a retrospective cohort study.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: Metabolic syndrome and minimal hepatic encephalopathy are both associated with impaired hepatic metabolic function. This study aimed to investigate their relationship in patients with cirrhosis and portal hypertension. Methods: This retrospective cohort study enrolled 127 patients. Minimal hepatic encephalopathy was diagnosed using the Psychometric Hepatic Encephalopathy Score. Restricted cubic spline and threshold analyses were used to assess dose-response relationships. Multivariable logistic and modified Poisson regression analyses were performed to identify independent predictors. Results: The prevalence of minimal hepatic encephalopathy was 17.3% (22/127). Patients with MHE had significantly higher fasting blood glucose (8.17 ± 4.36 vs. 5.33 ± 0.98 mmoL/L), and higher prevalence of metabolic syndrome and diabetes. Fasting blood glucose was an independent risk factor for MHE ( Conclusion: Metabolic disorders, especially hyperglycemia is closely associated with the occurrence of MHE in cirrhotic patients. Blood glucose control and comprehensive metabolic management may help reduce the risk of MHE.
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