Evidence map›Paper›PMID 42246193›Full record

ReviewInternational journal of molecular medicine2026

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review).

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Dai *Shanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Jiabin Wu *Shanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Xiaotong MaShanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Mingyu WuShanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Ke LiShanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Haoyang GaoShanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Wenhong WangShanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.
Weihua XiaoShanghai Key Laboratory of Human Performance (Shanghai University of Sport), Shanghai University of Sport, Shanghai 200438, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle atrophy (MA) is a major global health issue, and systematic strategies for its prevention and treatment are lacking. Diverse factors contribute to MA, amongst which the exogenous over‑supplementation and endogenous pathological elevation of glucocorticoids (GCs) are key causes. The present study summarizes MA induced by the GC dexamethasone (DEX) and its molecular mechanisms, including protein metabolism imbalance, mitochondrial dysfunction and abnormalities in epigenetic regulatory proteins, to explore potential therapeutic approaches for MA. FoxO transcription factor serves a central regulatory role in DEX‑induced MA by modulating the ubiquitin‑proteasome system, autophagy‑lysosomal system and energy metabolism pathways. Therefore, FoxO may serve as a critical therapeutic target for DEX‑induced MA. Plant‑derived natural products are promising candidates for the development of clinical drugs for tumors, myocardial infarction and diabetic nephropathy. These products protect against MA by regulating FoxO activity through multiple signaling pathways, including Akt, AMPK, and SIRT. Plant monomer compounds, such as flavonoids, polyphenols and terpenes, exert therapeutic effects and may provide new strategies for the precise prevention and treatment of MA induced by elevated GC levels.

Indexed as

Biological ProductsDexamethasoneForkhead Transcription FactorsMuscle, SkeletalMuscular AtrophyAnimalsHumansSignal TransductionBiological ProductsDexamethasoneForkhead Transcription FactorsdexamethasoneFoxOmuscle atrophyplant‑derived natural product

Identifiers

PMID42246193
PMCPMC13252942

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.