Evidence map›Paper›PMID 42246344›Full record

ArticleDermatology online journal2026

Lichen planus autoimmune comorbidities: A retrospective case control study.

Angela L Rosenberg, Alexander Wu, Lauren DeBusk, Apoorva Mehta, Brooke Bartley, Leah McAleer, Ryan Dominguez, Darrell Rigel, Melissa Mauskar, Joseph F Merola and 1 more

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Article in Dermatology online journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angela L RosenbergDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alexander WuDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lauren DeBuskDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Apoorva MehtaColumbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Brooke BartleyDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Leah McAleerDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ryan DominguezDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Darrell RigelDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Melissa MauskarDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joseph F MerolaDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kaveh NezafatiDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess whether patients with lichen planus (LP) show increased prevalence and odds of autoimmune and viral comorbidities compared with matched controls using real-world data.

methodsWe analyzed TriNetX Linked Network electronic health records and claims data from 2016 to 2024 (more than 112 million patients). LP was defined by at least 2 International Classification of Diseases, Tenth Revision, Clinical Modification codes (excluding drug-induced variants) and matched 1:1 to controls on age, sex, and race. We calculated odds ratios (ORs), 95% confidence intervals, prevalence, and absolute risk differences (ARDs).

resultsThe matched cohort included 43 458 LP and control patients (mean age, 53.8 years; 64.4% female). LP was associated with higher prevalence of autoimmune conditions, including psoriasis (6.59% versus 2.54%; ARD, 4.05%; OR, 2.71), lupus erythematosus (2.87% versus 1.13%; ARD, 1.74%; OR, 2.58), and autoimmune thyroiditis (3.09% versus 1.61%; ARD, 1.48%; OR, 1.95). Associations were also seen for Sjögren syndrome, alopecia areata, localized scleroderma, and vitiligo. Hepatitis C virus was more common in LP (2.95% versus 2.03%; ARD, 0.92%) but with a lower OR (1.47).

conclusionLP was associated with substantially higher odds and prevalence of several autoimmune comorbidities, exceeding those for viral infections such as hepatitis C. These findings inform LP pathogenesis and comorbidity patterns but do not support changes to clinical management.

Indexed as

Autoimmune DiseasesLichen PlanusAdultAgedAlopecia AreataCase-Control StudiesComorbidityFemaleHumansLupus Erythematosus, SystemicMaleMiddle AgedPrevalencePsoriasisRetrospective StudiesSjogren's Syndromeautoimmuneinflammatory disorderlichen planus

Identifiers

PMID42246344

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.