Evidence map›Paper›PMID 42247013›Full record

ArticleMolecular neurobiology2026

HM568 Enhances NAD

Minpeng Li, Wei Li, Yingjie Liu, Tingyuan Fu, Kaiye Peng, Changmei Wang, Jing Zhang, Yifan Feng, Xia Wu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minpeng LiNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Wei LiNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Yingjie LiuNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Tingyuan FuNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Kaiye PengNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Changmei WangNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Jing ZhangNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Yifan FengNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Xia WuNew Drug Research and Development Center, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China. wxiaxia@gdpu.edu.cn.

Funding

Medical Science and Technology Foundation of Guangdong Province A2023243Natural Science Foundation of Guangdong Province 2018A030313907
6 · The paper itself

Abstract

Parkinson's disease (PD) is closely associated with PARP1 overactivation. Although our previously developed compound HM568 has been shown to alleviate PD pathology, its mechanism of action remained unknown. In this study, we show that HM568 significantly improves behavioral deficits, prevents the loss of dopaminergic neurons, and restores blood-brain barrier integrity and mitochondrial morphology in MPTP/MPP

Indexed as

MitochondriaNADParkinson DiseasePoly (ADP-Ribose) Polymerase-11-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsDisease Models, AnimalDopaminergic NeuronsHumansMaleMiceMice, Inbred C57BLMolecular Docking Simulation1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineNADPoly (ADP-Ribose) Polymerase-1HM568Mitochondrial dysfunctionNAD+Parkinson's diseasePARP1

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.