ArticleMikrochimica acta2026
Dual-channel non-enzymatic sensor for comprehensive purine profiling: synergizing anodically pretreated boron-doped nanodiamond and Pd
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
The comprehensive profiling of purine metabolites-uric acid (UA), xanthine (XT), hypoxanthine (HX), and inosine (INO)-is vital for diagnosing metabolic disorders, yet remains analytically challenging due to severe overlap in oxidation potentials and the electrochemical inactivity of INO on conventional carbon surfaces. This work describes a label-free, dual-channel electrochemical platform utilizing disposable screen-printed graphene electrodes (SPGEs) to overcome these limitations. The architecture employs two spatially decoupled sensing modalities: (1) an anodically pretreated boron-doped nanodiamond (BDND) channel to resolve the UA-XT-HX kinetically triad, and (2) a Pd
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