Evidence map›Paper›PMID 42247156›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Silicone oil tamponade in vitreoretinal surgery and future perspective: a narrative review.

Cesare Mariotti, Alessio Muzi, Giulia Gregori, Oscar Matteo Gagliardi, Danilo Iannetta, Veronica Mogetta, Alberto Quarta, Maria Ludovica Ruggeri, Lorenzo Mangoni, Clara Rizzo and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cesare MariottiDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
Alessio MuziDepartment of Ophthalmology, Humanitas Gradenigo, Turin, Italy.
Giulia GregoriDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
Oscar Matteo GagliardiDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
Danilo IannettaDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
Veronica MogettaDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
Alberto QuartaDepartment of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.
Maria Ludovica RuggeriDepartment of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.
Lorenzo MangoniDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
Clara RizzoDepartment of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, Florence, Italy.
Rodolfo MastropasquaDepartment of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.
Marco LupidiDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy. m.lupidi@univpm.it.ORCID http://orcid.org/0000-0002-6817-2488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSilicone oil (SO) represents an essential ocular tamponade in complex vitreoretinal surgery, due to its transparency, chemical inertness, and long-term stability. This review aims to describe the current role of SO in vitreoretinal surgery, highlighting its indications, physicochemical characteristics, and the spectrum of associated complications. Special attention is given to the timing of removal and the balance between efficacy and safety.

methodsWe performed a narrative review of PubMed, Scopus and Google Scholar, focusing on indications, physicochemical determinants, complications and removal strategies of SO. The literature search was conducted up to January 2026. Inclusion was limited to English-language clinical and translational studies.

resultsSilicone oil provides a reliable long-term internal tamponade and contributes to favorable anatomical outcomes in eyes at high risk of recurrent retinal detachment. However, complications such as emulsification, ocular hypertension, corneal decompensation, cataract formation, and unexplained visual loss remain significant concerns. The risk of these adverse events increases with the duration of tamponade, underscoring the need for timely removal. Many centers plan removal around 3-6 months, tailored to retinal stability, IOP, and anterior SO migration. In selected cases with particularly severe or recurrent pathology, extended tamponade can still offer functional benefits and preserve useful vision.

conclusionSilicone oil continues to play a central role in complex vitreoretinal surgery. Careful patient selection, appropriate choice of oil formulation, meticulous surgical technique, and vigilant follow-up are critical to optimizing outcomes. Future directions should focus on the development of improved SO formulations and surgical strategies to enhance safety, minimize complications, and expand therapeutic indications.

Indexed as

EndophthalmitisHydrogelRetinal detachmentSilicone OilTamponade agent

Identifiers

PMID42247156

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.