Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex.

Maryama Mohamed, Ruikai Wu, Walid A Houry

Abstract readReview

In one paragraph

Review in Cell stress & chaperones, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maryama MohamedDepartment of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

Ruikai WuDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada.

Walid A HouryDepartment of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada. Electronic address: walid.houry@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The R2TP chaperone complex comprises two AAA+ proteins, RUVBL1 and RUVBL2, along with RPAP3 and PIH1D1. R2TP functions in concert with other chaperones, such as HSP90 and HSP70, to facilitate the assembly of macromolecular complexes integral to the regulation of cell growth and proliferation. Moreover, several adaptors interact with R2TP to impart substrate specificity. Nevertheless, the precise mechanism underlying R2TP-mediated complex assembly remains unknown. This review summarizes the current knowledge regarding R2TP's involvement in the assembly, stabilization, and activity of multiple protein complexes, including box C/D and H/ACA small nucleolar ribonucleoproteins (snoRNPs), spliceosome small nuclear ribonucleoproteins (snRNPs), the tuberous sclerosis complex (TSC) , axonemal dynein arms, RNA polymerases, phosphatidylinositol 3-kinase-related kinases (PIKK), and the MRE11-RAD50-NBS1 (MRN) complex. Additionally, the role of R2TP in ciliogenesis, circadian rhythm regulation, and transcriptional condensate formation is discussed. Finally, the latest structural studies pertaining to R2TP and its related complexes are examined.

Indexed as

ATPases Associated with Diverse Cellular ActivitiesCarrier ProteinsDNA HelicasesMolecular ChaperonesMultiprotein ComplexesAnimalsApoptosis Regulatory ProteinsHumansApoptosis Regulatory ProteinsATPases Associated with Diverse Cellular ActivitiesCarrier ProteinsDNA HelicasesMolecular ChaperonesMultiprotein ComplexesPIH1D1 protein, humanRPAP3 protein, humanRUVBL1 protein, humanRUVBL2 protein, humanChaperonesProtein assemblyProtein foldingProtein structureR2TP

Identifiers

PMID42248294

DOI10.1016/j.cstres.2026.100192

PMCPMC13284507

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.