ArticleThe Journal of biological chemistry2026
The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1.
Lauren K Anderson, Rohan Marde, Grace Muma, Veda Nayak, Chi Phan, Sheng Li, Jennifer N Cash
Abstract read
In one paragraphArticle in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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1 · What the graph read from itWhat it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Lauren K AndersonDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Rohan MardeDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Grace MumaDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Veda NayakDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Chi PhanDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Sheng LiDepartment of Medicine, University of California - San Diego, La Jolla, California, USA.
Jennifer N CashDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA. Electronic address: jcash@ucdavis.edu.
Funding
UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6MPacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5MChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2MStructural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling ScaffoldsR35GM146664 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jennifer Nicole Cash · 2022 to 2026
$2.0MNCATS NIH HHS UL1 TR001860NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R24 GM154185NIGMS NIH HHS R35 GM146664
6 · The paper itselfAbstract
Rho guanine-nucleotide exchange factors (RhoGEFs) activate small GTPases to drive cytoskeletal rearrangement, cell motility, and proliferation. The phosphatidylinositol-3,4,5-trisphosphate (PIP
Indexed as
Guanine Nucleotide Exchange FactorsRho Guanine Nucleotide Exchange FactorsCryoelectron MicroscopyHumansModels, MolecularGuanine Nucleotide Exchange FactorsPREX1 protein, humanRho Guanine Nucleotide Exchange Factorscryo-EMGTPaseinositol phosphateP-RexRacRhoGEF
Identifiers
PMID42248461
PMCPMC13355178
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