Evidence map›Paper›PMID 42248461›Full record

ArticleThe Journal of biological chemistry2026

The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1.

Lauren K Anderson, Rohan Marde, Grace Muma, Veda Nayak, Chi Phan, Sheng Li, Jennifer N Cash

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lauren K AndersonDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Rohan MardeDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Grace MumaDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Veda NayakDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Chi PhanDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA.
Sheng LiDepartment of Medicine, University of California - San Diego, La Jolla, California, USA.
Jennifer N CashDepartment of Molecular and Cellular Biology, University of California - Davis, Davis, California, USA. Electronic address: jcash@ucdavis.edu.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Structural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling ScaffoldsR35GM146664 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jennifer Nicole Cash · 2022 to 2026
$2.0M
NCATS NIH HHS UL1 TR001860NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R24 GM154185NIGMS NIH HHS R35 GM146664
6 · The paper itself

Abstract

Rho guanine-nucleotide exchange factors (RhoGEFs) activate small GTPases to drive cytoskeletal rearrangement, cell motility, and proliferation. The phosphatidylinositol-3,4,5-trisphosphate (PIP

Indexed as

Guanine Nucleotide Exchange FactorsRho Guanine Nucleotide Exchange FactorsCryoelectron MicroscopyHumansModels, MolecularGuanine Nucleotide Exchange FactorsPREX1 protein, humanRho Guanine Nucleotide Exchange Factorscryo-EMGTPaseinositol phosphateP-RexRacRhoGEF

Identifiers

PMID42248461
PMCPMC13355178

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.