Observational studyScientific reports2026
Prognostic evaluation of retinal reattachment surgery: predictive efficacy analysis of microperfusion indices via contrast-enhanced ultrasound.
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
Abstract
We aimed to examine how preoperative contrast-enhanced ultrasound (CEUS) parameters relate to postoperative visual recovery in retinal detachment (RD) patients and to establish new objective markers for clinical prognosis. This single-center prospective observational study enrolled 52 RD patients undergoing pars plana vitrectomy (PPV). Preoperative CEUS parameters (arrival time [AT], time to peak [TTP], peak intensity [PI], time-intensity curve-area under the curve [TIC-AUC], ascending slope [AS]) were collected. Between-group comparisons were performed using parametric or non-parametric tests as appropriate. Ocular covariates including RD duration, macular status, and tamponade type were adjusted in prespecified binary logistic regression models. (Patients were stratified into improvement (n = 39) and non-improvement (n = 13) groups based on 6-month best-corrected visual acuity. Model stability was validated using bootstrap resampling, and post-hoc power analysis was performed to confirm statistical reliability. Receiver operating characteristic (ROC) curves were generated to evaluate predictive performance. The improvement group exhibited significantly higher PI and TIC-AUC, and lower AT (all P < 0.05). TTP showed a borderline significant trend (P = 0.059), whereas AS showed no significant difference (P = 0.100). PI was the only independent CEUS predictor of visual improvement (Receiver operating characteristic-area under the curve [ROC-AUC] = 0.844, P < 0.001), accounting for 34.7% of the variance in visual improvement. Macular status was also an independent predictor. Bootstrap validation confirmed model robustness. Preoperative CEUS parameters, particularly PI, are associated with 6-month visual recovery after RD surgery. PI represents a preliminary candidate prognostic biomarker; caution is needed for clinical translation owing to the single-center design, small sample size, and absence of external validation. Multicenter studies are needed to validate these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.