Evidence map›Paper›PMID 42249031›Full record

ArticleScientific reports2026

Quantitative detection of macrophage activation in osteosarcoma comparing

Raheleh Roudi, Frezghi Habte, Giovanni Marco Saladino, Iryna Vasyliv, Laura Pisani, Jason Wong, Ali Syed, Heike E Daldrup-Link

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raheleh RoudiDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Frezghi HabteDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Giovanni Marco SaladinoDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Iryna VasylivDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Laura PisaniDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Jason WongDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Ali SyedDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Heike E Daldrup-LinkDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA. heiked@stanford.edu.

Funding

Co-Clinical Research Resource for Imaging Tumor Associated MacrophagesU24CA264298 · NCI · STANFORD UNIVERSITY · PI DALDRUP-LINK, HEIKE ELIZABETH, GATIDIS, SERGIOS · 2021 to 2025
$3.2M
NCI NIH HHS U24 CA264298
6 · The paper itself

Abstract

Targeting CD47 with monoclonal antibody (mAb) therapy activates tumor-associated macrophages (TAMs). Quantitative imaging methods are important for identifying responders to this novel immunotherapy. The purpose of our study was to investigate whether the metabolic activity of osteosarcomas on

Indexed as

Bone NeoplasmsFerrosoferric OxideFluorodeoxyglucose F18Macrophage ActivationMagnetic Resonance ImagingOsteosarcomaPositron Emission Tomography Computed TomographyAnimalsAntibodies, MonoclonalCD47 AntigenCell Line, TumorFemaleHumansMacrophagesMaleMiceAntibodies, MonoclonalCD47 AntigenFerrosoferric OxideFluorodeoxyglucose F1818F-FDGCD47FerumoxytolImmunotherapyMRIOsteosarcomasPET/CT

Identifiers

PMID42249031
PMCPMC13482818

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.