Trial reportBMC oral health2026
Does minimally invasive non-surgical therapy improve outcomes in splinted mandibular incisors? Results from a randomized trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06772506 (Clinical and Patient-centered Outcomes After Minimally Invasive Non-surgical Therapy for the Treatment of Splinted Stage IV Periodontitis - Randomized Controlled Clinical Trial), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Patient-centered Outcomes After Minimally Invasive Non-surgical Therapy for the Treatment of Splinted Stage IV Periodontitis - Randomized Controlled Clinical Trial
Who cites it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConventional non-surgical periodontal therapy (CNST) is an effective method for managing mild to moderate periodontitis. However, in cases of severe periodontitis, CNST may leave residual pockets. Severe periodontitis, particularly in stages III and IV, often involves significant tooth mobility, which may require the use of a permanent splint. Minimally invasive non-surgical techniques (MINST) have been proposed to deliver better results and enhance patient satisfaction. However, current evidence does not decisively evaluate the outcomes of splinted teeth following MINST. Therefore, this research aimed to address the knowledge gap by assessing the clinical outcomes of MINST compared to CNST in the treatment of splinted teeth affected by stage III and IV periodontitis.
methodsA parallel-arm, single-blind randomized controlled trial was conducted on 39 patients (46 sites) with stage III-IV periodontitis and grade II-III mobility of mandibular incisors. Participants were randomly assigned to conventional non-surgical therapy (CNST) or minimally invasive non-surgical therapy (MINST), both of which included splinting. Outcomes were assessed at baseline, 3, and 6 months. The primary outcome was pocket reduction, assessed by changes in probing pocket depth (PPD) from baseline to follow-up. Secondary outcomes included pocket closure (PC), defined as the proportion of sites with PPD ≤ 4 mm and no bleeding on probing (BOP), derived from these measurements; clinical attachment level (CAL); defect bone fill (DBF); and patient satisfaction.
resultsBoth groups showed significant reductions in probing pocket depth and gains in CAL (p < 0.001). Pocket closure occurred more frequently in the MINST group (65.2%) compared to the CNST group (39.1%) at 6 months (p = 0.015). Radiographic bone fill improved significantly in both groups, with no intergroup difference. Patient satisfaction was similar (NPS: CNST = 38; MINST = 42; p = 0.39).
conclusionBoth MINST and CNST with splinting improved periodontal outcomes, but MINST achieved a higher rate of pocket closure, while radiographic bone fill and patient satisfaction were comparable between groups.
trial registrationCurrent Controlled Trials: NCT06772506. The date of registration in the (2025-01-03) "Retrospectively registered".
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