ArticleBMC surgery2026
Plasma albumin and other indicators as risk factors for delayed neurocognitive recovery in elderly patients undergoing orthopedic surgery.
Article in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe risk factors for neurocognitive impairment outcomes vary among different types of surgeries. The risk factors for delayed neurocognitive recovery (DNR) in elderly patients following orthopedic surgery are unclear. The objective of this study was to identify the risk factors for early postoperative delayed neurocognitive recovery in elderly patients who underwent elective orthopedic surgery.
methodsThe medical data of 166 elderly patients underwent elective orthopedic procedures were analyzed retrospectively. The cognitive scores on the day before the surgery and on the 7th postoperative day were assessed using the MoCA scale, and Z-scores were utilized to account for learning effects. The study population was divided into two groups according to whether DNR occurred by the 7th postoperative day or prior to discharge. Risk factors associated with postoperative DNR in elderly orthopedic patients were determined using logistic regression analysis.
resultsThere were 166 elderly surgical patients, with an incidence rate of 28.9% DNR. Multivariate logistic regression analysis revealed that a history of drinking (OR = 6.853 [1.825-25.734], P = 0.004), cerebrovascular stenosis (mild: OR = 7.646 [1.432-40.833], P = 0.017; moderate or severe: OR = 5.593 [1.222-25.607], P = 0.027), a preoperative PaO
conclusionEarly DNR in elderly orthopedic patients appears to be associated with multiple factors, including a history of drinking, cerebrovascular stenosis, a preoperative PaO₂/FiO₂ ratio < 350, and postoperative albumin < 35 g/L.
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