Evidence map›Paper›PMID 42249728›Full record

ReviewHistopathology2026

The 2025 ATS/ERS update of the international multidisciplinary classification of the interstitial pneumonias: implications for the pathologist.

Andrew G Nicholson, Wendy A Cooper, Aurelie Fabre, William Travis, Lida P Hariri, Ayodeji Adegunsoye, Sara Piciucchi, Christopher J Ryerson

Abstract readReview
In one paragraph

Review in Histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew G NicholsonDepartment of Histopathology, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, National Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-3257-102X
Wendy A CooperTissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.ORCID https://orcid.org/0000-0001-5418-4229
Aurelie FabreHistopathology Department, St Vincent's University Hospital, Dublin, Ireland.ORCID https://orcid.org/0000-0001-8176-1386
William TravisDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID https://orcid.org/0000-0003-3160-6729
Lida P HaririDepartment of Pathology and Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-6190-624X
Ayodeji AdegunsoyeDepartment of Medicine, Section of Pulmonary & Critical Care, University of Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-7015-9610
Sara PiciucchiDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-6608-0574
Christopher J RyersonDepartment of Medicine and Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0003-1049-393X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

A consensus classification for idiopathic interstitial pneumonias was first published in 2002, providing terminology for clinicians, radiologists and pathologists as well as highlighting that a multidisciplinary approach was best clinical practice. This comprised seven histological patterns that had corresponding idiopathic multidisciplinary diagnoses. This classification was updated in 2013, with the addition of an eighth histological pattern. Since 2013, there have been further advances in our understanding of interstitial pneumonias, in particular relating to idiopathic versus secondary disease, advances in molecular pathology and recognition of progressive pulmonary fibrosis (PPF), which have led to a further update in 2025. This review highlights the changes relevant to pathologists reporting interstitial pneumonias. Major changes include (1) expansion beyond idiopathic interstitial pneumonias to also include secondary causes, (2) subclassification as interstitial (fibrotic vs non-fibrotic) and alveolar filling disorders, (3) expansion to include additional patterns (e.g. bronchiolocentric interstitial pneumonia), (4) improved terminology that better reflects histogenesis and (5) consideration of diagnostic confidence in biopsy evaluation. Pathologists also need to be aware of the advantages and limitations of cryobiopsy interpretation and the importance of reporting features that point towards a secondary cause rather than idiopathic disease. The 2025 classification provides a framework for a methodological approach to reporting biopsies in patients with interstitial pneumonia, which should be used prospectively for both diagnosis and research.

Indexed as

Lung Diseases, InterstitialBiopsyHumansIdiopathic Interstitial PneumoniasLungPathologistsclassificationdiagnosisinterstitial lung diseasepathologypulmonary fibrosis

Identifiers

PMID42249728
PMCPMC13441401

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.