ArticleAdvances in therapy2026
Once-Weekly Subcutaneous Semaglutide 2.4 mg Injection is Cost-Effective for Weight Management in Spain.
Article in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
introductionA current major challenge for national health systems (NHS) is the increase of obesity and overweight among populations. Subcutaneous semaglutide 2.4 mg, a glucagon-like peptide 1 analogue, has been approved by the European Medicines Agency as an adjunct to a reduced-calorie diet and increased physical activity (diet and exercise [D&E]) for the treatment of obesity. The aim of this study was to evaluate the cost-effectiveness of semaglutide 2.4 mg in combination with D&E compared with D&E alone in the treatment of patients with obesity in Spain.
methodsThe analyses were performed using version 26 of the Core Obesity Model, a Markov state transition model, to project health outcomes and costs at 40 years, based on the evolution of risk factors associated with obesity. Efficacy and safety data were obtained from the STEP 1 trial (body mass index [BMI], systolic blood pressure and glycaemic status), involving a cohort of adults with an average age of 46 years and obesity (BMI ≥ 30 kg/m
resultsCompared with D&E, semaglutide 2.4 mg in combination with D&E generated an additional 0.1049 QALYs and a €2685 increase in costs over 40 years, resulting in an incremental cost-effectiveness ratio of €25,589/QALY. Semaglutide 2.4 mg was shown to be cost-effective under a cost-effectiveness threshold of €30,000/QALY. The robustness of this finding was confirmed by the sensitivity analyses and scenarios evaluated.
conclusionsOn the basis of the model-based analysis, semaglutide 2.4 mg, in combination with D&E, was estimated to be a cost-effective therapeutic alternative in Spain for adults with obesity, compared to treatment based on D&E alone. These results may be useful for optimizing decision-making.
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