Trial reportThe Journal of pediatrics2026
The MIND Randomized Controlled Trial: An Intervention to Improve Neural Speech Processing and 2-Year Language Outcomes of Infants Born Preterm.
Trial report in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03232931 (Randomized Controlled Trial to Improve Multisensory Neural Processing, Language & Motor Outcomes in Preterm Infants), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial to Improve Multisensory Neural Processing, Language & Motor Outcomes in Preterm Infants
Who cites it
1 citing paper in PubMed.
- Recorded Contingent Caregiver Voice Independently Improves Neural Speech Processing in Hospitalized Preterm Infants: A Multisite Randomized Controlled Trial.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesTo assess whether contingently administered caregivers' infant-directed voice in a multisensory intervention would have a larger effect than standard care on preterm neural speech-sound differentiation and to determine if effects of the intervention causally mediated differences in 2-year language outcomes. STUDY
designA randomized controlled trial of the MIND (Multisensory support to Improve Neural processing and Development) intervention (contingent caregiver's recorded voice, scent cloth, holding by therapist in kangaroo binder; 20 sessions, 20 minutes each, over 2-3 weeks) compared with an enhanced standard care control (passive listening to recorded caregiver's voice, same dose) starting at 32-36 weeks of corrected gestational age (GA) among infants in the neonatal intensive care unit. Speech-sound differentiation was measured by auditory time-locked electroencephalogram (EEG) pre- and post-intervention and language outcomes using Bayley Scales of Infant and Toddler Development and Preschool Language Scales at 2 years. Analyses were conducted through ANCOVA and causal mediation modeling.
resultsOf enrolled infants (mean GA 28.8 weeks), 100 completed MIND and 98 completed enhanced standard care, with usable EEG data pre- and post-intervention. Infants receiving MIND had greater neural speech-sound differentiation compared with controls (F ranging 5.33-7.87; P ranging .03 to .04). MIND effects included small-to-medium size effects on language outcomes that were mediated by EEG with total effects model R
conclusionsMIND, a parent-supported, therapist-implemented intervention, can improve preterm speech-sound differentiation in the neonatal intensive care unit and 2-year language outcomes. Efficacious parent-engaging neuropromotive interventions can change neurodevelopment, even without bedside presence.
trial registrationClinicalTrials.gov NCT03232931.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.