Evidence map›Paper›PMID 42251338›Full record

ReviewCell communication and signaling : CCS2026

Decoding TNF receptor superfamily control of CD4

Chon-Kit Chou, Xinyang Wang, Ruiqi Yu, Hang Xu, Yibo Chen, Yang Yang, Zhonghao Chen, Chuangen Li, Tianzhen He, Xin Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chon-Kit Chou *State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China. ckchou@um.edu.mo.
Xinyang Wang *State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Ruiqi YuState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Hang XuState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Yibo ChenState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Yang YangState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Zhonghao ChenState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Chuangen LiState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China.
Tianzhen HeInstitute of Pain Medicine and Special Environmental Medicine, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China. sailing198562@ntu.edu.cn.
Xin ChenState Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, 999078, China. xchen@um.edu.mo.

Funding

The Science and Technology Development Fund, Macau SAR FDCT, File No. 0048/2024/ITP2, 0007/2022/AKP, 005/2023/SKL, 0001/2025/AKP, 0002/2025/NRP, and 0008/2025/EQPUniversity of Macau File No. SRG2022-00042-ICMS and MYRG-GRG2024-00245-ICMS-UMDF
6 · The paper itself

Abstract

Allogeneic transplantation is a cornerstone treatment for hematologic malignancies and organ failure, yet its success is limited by graft-versus-host disease (GvHD) and allograft rejection. Conventional broad-spectrum immunosuppression compromises protective graft-versus-leukemia (GvL) effects and anti-infectious immunity, creating an urgent need for precision tolerance strategies. CD4

Indexed as

Forkhead Transcription FactorsGraft vs Host DiseaseImmune ToleranceReceptors, Tumor Necrosis FactorT-Lymphocytes, RegulatoryAnimalsHumansForkhead Transcription FactorsFOXP3 protein, humanReceptors, Tumor Necrosis FactorGvHDTNF Receptor SuperfamilyTNFRSFTolerance.TransplantationTreg ExpansionTregs

Identifiers

PMID42251338
PMCPMC13277113

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.