Evidence map›Paper›PMID 42251639›Full record

ArticleMacromolecular bioscience2026

Fully Synthetic, Biomimicking Polysulfates With Tunable Anticoagulant and Endothelial Cell-Selective Bioactivity.

Andrea Cosimi, Roxana Pollehn, Andrea De Martino, Scarlett Manzke, Yannic Kerkhoff, Philip Nickl, Theresa Lohmann, Eriselda Keshi, Cornelia Lee-Thedieck, Marie Weinhart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea CosimiInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.
Roxana PollehnInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.
Andrea De MartinoInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.
Scarlett ManzkeInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.
Yannic KerkhoffInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.
Philip NicklInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.
Theresa LohmannDepartment of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin, Germany.
Eriselda KeshiDepartment of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1780-9151
Cornelia Lee-ThedieckInstitute of Cell Biology and Biophysics, Leibniz Universität Hannover, Hannover, Germany.ORCID https://orcid.org/0000-0001-8863-5403
Marie WeinhartInstitute of Chemistry and Biochemistry - Organic Chemistry, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-5116-5054

Funding

German Federal Ministry of Research and Education 13N13523German Research Foundation project ID 506711010Zukunft.Niedersachsen program of the State of Lower Saxony ZN 4344
6 · The paper itself

Abstract

We present a versatile method for fabricating glycosaminoglycan (GAG)-inspired polyelectrolyte brush coatings from fully synthetic sulfated PHEMA block copolymers. Using a bioinert backbone enables evaluation of sulfation effects independently of natural GAGs' carbohydrate backbone. A degree of sulfation above 70% imparted anticoagulant activity, extending plasma coagulation times beyond 500 s at 0.1 mg mL

Indexed as

AnticoagulantsBiomimetic MaterialsHuman Umbilical Vein Endothelial CellsSulfatesCell ProliferationCoculture TechniquesGlycosaminoglycansHumansMyocytes, Smooth MuscleVascular Endothelial Growth Factor AAnticoagulantsGlycosaminoglycansSulfatesVascular Endothelial Growth Factor AGAG‐mimeticgrowth factor sequestrationin vitro reendothelializationpolyelectrolyte brushessulfated PHEMA

Identifiers

PMID42251639
PMCPMC13242835

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.