ArticleExperimental hematology2026
Image-enabled cell sorting permits prospective isolation of primitive hematopoietic stem cell subsets with distinct functional potential.
Article in Experimental hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fluorescence-activated cell sorting (FACS) has been a core technology for the identification, characterization and isolation of hematopoietic stem cells (HSCs), allowing for prospective isolation of cells which express specific molecules at specific levels of intensity. A recent technological breakthrough, image-enabled cell sorting (ICS), is based on FACS but it also permits separation of cells based on the differential distribution of these molecules across the cell. Using ICS in primary HSCs, we surveyed the patterns of expression for a range of intracellular markers and identified mitochondrial dyes as a tool to prospectively isolate HSCs with different properties. Integration of index-sort data with single-cell divisional kinetics identified total intensity and diffusivity of the MitoTracker dye as parameters enabling prospective isolation of functionally heterogeneous HSCs. In vivo functional assays confirmed that HSCs capable of long-term multilineage contribution were highly enriched in the MitoTracker low diffusivity, low intensity populations. Moreover, HSCs displaying high MitoTracker intensity but low MitoTracker diffusivity (Mito
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