In one paragraphArticle in British journal of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Suvankar GhoshDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Computer-Aided Drug Design Center, University of Maryland, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-4612-8021 Alexander D MacKerellDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Computer-Aided Drug Design Center, University of Maryland, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-8287-6804 Funding
Strategies for biasing and augmenting b2-adrenoceptor signaling and function in ASMP01HL180318 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI RAYMOND B. PENN · 2025 to 2026
$7.1MDiacylglycerol kinase in airway smooth muscle functionsR01HL146645 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KAMBAYASHI, TAKU · 2019 to 2024
$2.8MRole of tRNA- and rRNA-derived RNAs in acute lung injuryR01HL175371 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Deepak A Deshpande, Yohei Kirino · 2024 to 2026
$1.9MAllosteric modulation of beta2- adrenoceptors in the treatment of asthmaR01HL173113 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Deepak A Deshpande · 2024 to 2026
$1.7MOptimizing function-selective ERK1/2 inhibitors for reducing AP-1-mediated airway pathology in asthma.R61HL168723 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI DESHPANDE, DEEPAK A, SHAPIRO, PAUL S · 2023 to 2024
$1.0MOptimizing function-selective ERK1/2 inhibitors for reducing AP-1-mediated airway pathology in asthma.R33HL168723 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI DESHPANDE, DEEPAK A, SHAPIRO, PAUL S · 2025 to 2025
$362kAmerican Heart Association 24PRE1183692NHLBI NIH HHS HL146645NHLBI NIH HHS HL168723NHLBI NIH HHS HL173113NHLBI NIH HHS HL180318NHLBI NIH HHS P01 HL180318NHLBI NIH HHS R01 HL146645NHLBI NIH HHS R01 HL173113NHLBI NIH HHS R01 HL175371NHLBI NIH HHS R33 HL168723NHLBI NIH HHS R61 HL168723
6 · The paper itselfAbstract
background and purposeβ EXPERIMENTAL APPROACH: The effects of a positive AM (PAM37) and two negative AMs (NAM36 and NAM42) were examined on β-agonist-induced Gαs and β-arrestin recruitment and downstream signalling (cAMP, PKA and ERK) in HEK293 cells expressing β KEY
resultsPAM37 enhanced, whereas NAMs attenuated β CONCLUSIONS AND IMPLICATIONS: These findings establish orthosteric ligand-dependent allostery as a fundamental feature of β
Indexed as
Adrenergic beta-2 Receptor AgonistsBronchodilator AgentsGTP-Binding Protein alpha Subunits, GsReceptors, Adrenergic, beta-2Allosteric RegulationAnimalsHEK293 CellsHumansLungMaleMiceMice, Inbred C57BLMolecular Dynamics SimulationProtein ConformationSignal TransductionAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsGTP-Binding Protein alpha Subunits, GsReceptors, Adrenergic, beta-2adrenergic receptorallosteric modulatorasthmabiased agonismG protein‐coupled receptorpharmacologyβ‐agonist
Identifiers
PMID42252113
PMCPMC13583984
What Socratic holds
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